e-POSTER PRESENTATIONS

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P1 - Emerging concepts / novel agents

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• P01.01 - A Phase 1a/1b Dose-escalation Study of Intravenously Administered SB 11285 Alone and in Combination with Nivolumab in Patients with Advanced Solid Tumors

Atif Abbas, Hopkinton, United States

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• P01.02 - HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer

Yan Asmann, Jacksonville, United States

 

• P01.03 - VOC Pattern Recognition of Lung Cancer: a Comparative Evaluation of Different Dog- and eNose-Based Strategies Using Different Sampling Materials

Wiebke Biehl, Munich, Germany

 

• P01.05 - Development of signal amplification for spatially-resolved, highly multiplexed biomarker analysis of human tumor tissues.

Oliver Braubach, Menlo Park, United States

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• P01.06 - Spatially-resolved, highly multiplexed biomarker analysis of cancerous and normal human breast tissues.

Oliver Braubach, Menlo Park, United States

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• P01.08 - Beyond PD-1: Characterization of new checkpoints restricting function of cytotoxic lymphocytes infiltrating human carcinoma

Anna Herbstritt, München, Germany

 

• P01.09 - Dual signalling protein 107 triggers innate and adaptive immune response towards tumour cells

Lisa Jacob, Groningen, Netherlands

 

• P01.10 - IFNy secretion of adaptive and innate immune cells as a parameter to display leukaemia derived dendritic cell (DCleu) mediated immune responses in AML

Lara Klauer, Munich, Germany

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• P01.11 - Role of Exosomes as promotors or biomarkers to study activation of leukemia-derived dendritic cells (DCleu)-mediated antileukemic activation of adaptive and innate immune-reactive cells against AML-blasts

Lin Li, Munich, Germany

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• P01.12 - Impact of complementary substances on immune cell activity

Martin Luzbetak, Munich, Germany

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• P01.13 - MERTK signaling is critical for T cell proliferation and memory

Richard Powell, Herlev, Denmark

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• P01.14 - Excessive biological ageing of circulating neutrophils in cancer promotes tumor progression

Christoph Reichel, Munich, Germany

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• P01.15 - Personalized combination of neoadjuvant domatinostat, nivolumab (NIVO) and ipilimumab (IPI) in macroscopic stage III melanoma patients stratified according to interferon-gamma (IFN-gamma) signature - the DONIMI study

Irene Reijers, Amsterdam, Netherlands

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• P01.16 - Effects of the STAT3 inhibitors on senescent tumour cells

Olena Sapega, Prague, Czech Republic

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• P01.17 - Tim-3/Galectin-9 pathway controls the ability of malignant cells to escape host immune surveillance. Regulatory mechanisms and therapeutic targets

Vadim Sumbayev, Chatham Maritime, United Kingdom

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• P01.18 - Metabolic status and immune activation influence clinical outcomes in patients after allogeneic hematopoietic stem cell transplantation

Sebastian Theurich, Munich, Germany

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• P01.20 - Tim-3-galectin-9 immunosuppressive pathway in human liquid and solid tumours

Inna Yasinska, Chatham Maritime, United Kingdom

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• P01.22 - Extending CAR T cell therapy applications via drug inducible control of transgene expression

Bettina Kotter, Bergisch Gladbach, Germany
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• P01.23 - Creating a cell-culture based reporter system for the evaluation of molecular signaling mechanisms of inhibitory chimeric antigen receptors

Maximilian Funk, Vienna, Austria
 

• P01.24 - The selective HDAC6 inhibitor ITF3756 increases the differentiation to central memory T cells with reduced exhaustion phenotype

Gianluca Fossati, Cinisello Balsamo, Italy
 

P2 - Microbiome and immune system/immunotherapy

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• P02.01 - Predictive impact of the gut microbiota on treatment response to CD19 specific CAR T-cells

Viktoria Blumenberg, Munich, Germany

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• P02.02 - Generating neo- and self-antigen screening libraries for class II HLA presentation

Veronica Pinamonti, Heidelberg, Germany

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• P02.03 - Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma

Martin Thelen, Köln, Germany​

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P3 - Tumor microenvironment

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• P03.01 - Prevalence of CD112R+ immune cells in normal lymphatic tissues, inflammation and the cancer microenvironment

Niclas Blessin, Hamburg, Germany

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• P03.02 - Suppression of T-cell proliferation and cytokine release by the adenosine axis are mediated by different mechanisms

Julia Festag, PLANEGG/ MARTINSRIED, Germany

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• P03.03 - Organization, function and gene expression of tertiary lymphoid structures in PDAC resembles lymphoid follicles in secondary lymphoid organs

María García-Márquez, Cologne, Germany

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• P03.04 - Applying Multispectral Unmixing and Spatial Analyses to Explore Tumor Heterogeneity with a Pre-Optimized 7-color Immuno-Oncology Workflow

Virginie Goubert, Marlborough, United States

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• P03.05 - Deep Spatial Profiling of the Immune Landscape of MSI and MSS Colorectal Tumors

Mathias Holpert, Seattle, United States

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• P03.06 - Pattern of Ki67+ expanding CD8+ cytotoxic T cells in healthy tissues, inflammation and the cancer microenvironment

Claudia Hube-Magg, Hamburg, Germany

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• P03.07 - Fast automated microfluidic-based multiplexed immunofluorescence for tumor microenvironment analysis

Alexandre Kehren, Lausanne, Switzerland

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• P03.10 - Prevalence and prognostic role of FoxP3⁺regulatory T lymphocytes in cancer. A tissue microarray study on >20’000 cancers

Tim Mandelkow, Hamburg, Germany

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• P03.11 - Exploring tumor-intrinsic factors regulating the recruitment of myeloid-derived suppressor cells (MDSC) in pancreatic ductal adenocarcinoma

Carlotta Rambuscheck, München, Germany

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• P03.13 - Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and reduce response to immune-oncology treatments

Suzanne Sitnikova, Cambridge, United Kingdom

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• P03.15 - Site-specific immune evasion and substantial heterogeneity within entities provide evidence for personalized immunotherapy

Martin Thelen, 50931, Germany

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• P03.16 - Functional Defects in B-cells of Patients with von-Hippel-Lindau Syndrome

Sebastian Theurich, Munich, Germany

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• P03.17 - uPA-PAI-1 heteromers promote advanced stages of breast cancer by attracting pro-tumorigenic neutrophils

Bernd Uhl, München, Germany

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• P03.19 - Evaluation of immunogenicity differences in LLC1 and GL261 tumor models for effective chemo-immunotherapy treatment

Karolina Zilionyte, Vilnius, Lithuania

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• P03.20 - A murine, myc-driven lymphoma model expressing human CD22 enables testing of targeted therapies and their effects on tumor immune microenvironment
  Fabian Müller, Erlangen, Germany
   

• P03.21 - Projecting T cells into a reference transcriptomic atlas to interpret antitumor immune responses

Santiago Carmona, Epalinges, Switzerland

 

• P03.22 - Repolarization of tumor-associated macrophages for immunotherapy of tumors with diverse major histocompatibility complex class I expression
  Adrianna Piataková, Prague 2, Czech Republic
   

• P03.23 - Evolution of the immune landscape within partially controlled murine melanoma
  Chen Qing, London, United Kingdom
   

• P03.26 - Immunoprofiling of oral and oropharyngeal tumors of different etiology

Barbora Pokrývková, Vestec, Czech Republic
 

• P03.27 - Role of NOX2 for hypoxia-induced chemoresistance in acute myeloid leukemia
  Sanchari Paul, Gothenburg, Sweden
   

• P03.28 - Structural characteristics in tumor and lymph nodes as predictors of 3-year metastasis-free survival in surgically treated NSCLC
  Laura Sellmer, Munich, Germany
   

• P03.29 - Characterization of treatment-induced adaptive immune responses in pancreatic ductal adenocarcinoma
  Jeannine Heetmeyer, München, Germany
   

• P03.31 - Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

Natasa Prokopi, Amsterdam, Netherlands

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P4 - Vaccine Therapy

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• P04.01 - Dendritic-cell based immunotherapy targeting pancreatic and NSCLC cancer stem cells

João Calmeiro, Coimbra, Portugal

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• P04.02 - A novel Cancer immunotherapy combines rMVA-CD40L with tumor targeting antibodies

Maria Hinterberger, Martinsried, Germany

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• P04.03 - Immune modulatory vaccine directed against IDO1-expressing immune cells elicits T cell-mediated anti-tumor immunity and enhances anti-PD1 responses

Ayako Pedersen, Copenhagen, Denmark

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• P04.04 - Multifunctional antibody construct for in vivo targeting of dendritic cells as a therapeutic vaccination strategy in AML

Saskia Schmitt, München, Germany

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• P04.05 - Modulating tumor microenvironment with arginase-1 specific T cells
  Evelina Martinenaite, Copenhagen, Denmark
   

• P04.06 - Mucosal immunization with a cDC1-targeted CTA1 adjuvant vaccine confers protection against melanoma metastasis

Mohammad Arabpour, Göteborg, Sweden
 

• P04.08 - Virus like vaccines: a novel immunotherapy strategy against the cancer-associated endogenous retrovirus

Joana Daradoumis, Copenhagen, Denmark
 

• P04.09 - Development of a dendritic cell vaccine against hepatocellular carcinoma using VSV-NDV

Julia Gold, München, Germany
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P5 - Precision Medicine Meets Immunotherapy (Immuno-Monitoring)

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• P05.01 - Comparative analysis of RNA versus DNA as input material for IGH repertoire sequencing panels for immuno-oncology applications and rare clone detection

Geoffrey Lowman, Carlsbad, United States​

 

P6 - Cell Therapy in Solid Tumors

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• P06.01 - ​Bispecific antibody-driven synthetic agonistic receptor - transduced T cells mediate specific and conditional therapy in melanoma cancer models

Mohamed-Reda Benmebarek, Munich, Germany

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• P06.03 - ​C-C chemokine receptor 8 tumor-directed recruitment enables CAR T cells to reject solid tumors

Bruno L. Cadilha, München, Germany

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• P06.05 - ​IDO1-deleted CAR T cells show improved therapeutic efficacy in murine pancreatic cancer models

Anne Senz, München, Germany

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• P06.06 - ​Adoptive cell therapy of triple negative breast cancer with redirected Cytokine-Induced Killer cells

Annavera Ventura, Padova, Italy

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• P06.07 - ​CXCR6 expression enhances accumulation of anti-mesothelin CAR T cells at the tumor site and their therapeutic efficacy in pancreatic cancer xenografts

Adrian Gottschlich, Munich, Germany

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• P06.09 - ​Anti-hPSMA CAR engineered NK-92 cells: An off-the-shelf cellular therapeutic for targeted elimination of prostate cancer cells

Alessandro Penna, Padova, Italy

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• P06.10 - ​Short term inhibition of checkpoint proteins increases ex vivo expansion of tumour infiltrating lymphocytes in high grade serous ovarian cancer
  Caitlin Waddell, Manchester, United Kingdom
   

• P06.11 - ​Immunotargeting of CD98hc for Elimination of Radioresistant Head and Neck Squamous Cell Carcinoma
  Ayse Köseer, Dresden, Germany
   

• P06.12 - ​Combination therapy of CAR-NK-cells and anti-PD-1 antibody results in high efficacy against advanced-stage glioblastoma in a syngeneic mouse model and induces protective anti-tumor immunity in vivo

Michael Burger, Frankfurt, Germany

 

• P06.13 - ​A novel local treatment approach? Targeted immunotherapy of glioblastoma via AAV-mediated gene transfer of checkpoint inhibitors through locally administered HER2-AAVs in combination with CAR-NK cells

Michael Burger, Frankfurt, Germany

 

• P06.14 - ​Characterization of tumor-infiltrating T cells by highly multiplexed immunofluorescence imaging

Elvira Criado-Moronati, Bergisch Gladbach, Germany

 

• P06.15 - ​Highly Multiplexed, Single-Cell Functional Proteomics of CAR-T Products Enables More Predictive Product Characterization, Cell Manufacturing Optimization, and Cellular Biomarkers across Product Types

Dong Liu, Branford, United States​

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P7 - Cell Therapy in Haematologic Diseases

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• P07.01 - ​CD19 CAR T-cells for relapsed/refractory Diffuse Large B-Cell Lymphoma: Real-world data from LMU Munich

Veit Bücklein, Munich, Germany

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• P07.02 - ​High-affinity TCRs specific for Cancer Testis Antigens as a therapy for multiple myeloma and solid tumors

Marije de Rooij, Leiden, Netherlands

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P8 - Combination Therapy

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• P08.01 - ​Low-dose Checkpoint inhibitors with hyperthermia and IL-2 are safe and effective in stage IV cancer with unfavorable immunological profile (MSI low, PD-L1 under 1%, TMB low) - A single-institution experience from 2015 to 2020

Ralf Kleef, Vienna, Austria

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• P08.03 - ​Combining PD-1/PD-L1 blockade and RANKL inhibitors to treat breast cancers unresponsive to standard therapy

Charlotte Pilard, Liège, Belgium

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• P08.04 - ​​Neoadjuvant chemoradiotherapy with sequential ipilimumab and nivolumab in rectal cancer (CHINOREC): a prospective randomized, open-label, multicenter, phase II clinical trial

Johannes Laengle, Vienna, Austria

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P9 - Young Researchers Session

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• P09.01 - ​​Adoptive cell therapy of hematological malignancies using Cytokine-Induced Killer cells retargeted with monoclonal antibodies

Anna Dalla Pietà, Padua, Italy

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• P09.02 - ​​​Mapping and tackling tumor and chemotherapy-induced immune suppression in breast cancer sentinel lymph nodes

Natasa Prokopi, Amsterdam, Netherlands

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• P09.03 - ​​​Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma

Johannes Hildebrand, Munich, Germany

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• P09.04 - ​​​Oncolytic H5N1 influenza strain displays superior therapeutic properties independent of immuno-stimulatory interleukin-2 transgene expression

Julijan Kabiljo, Vienna, Austria

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• P09.05 - ​​​Immunogenicity induced by the academic Chimeric Antigen Receptor CAR19 (ARI-0001) in patients with CD19-positive relapsed/refractory B-cell malignancies recruited into the CART19-BE-01 clinical trial

Nela Klein-González, Barcelona, Spain

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• 09.07 - ​​​An immune modulatory vaccine targeting CCL22 promotes anti-tumor immunity

Inés Lecoq, København, Denmark

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• P09.08 - ​​​Clinical-grade manufacturing of ROR1 CAR T cells using a novel virus-free protocol

Katrin Mestermann, Würzburg, Germany

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• P09.09 - ​​​PD-1 checkpoint blockade for treatment of mucormycosis and invasive aspergillosis in a stem cell transplant recipient

Niklas Mueller, Munich, Germany

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• P09.10 - ​​​Local immunotherapy of brain cancer harnessing high-retention Fc-fusion constructs

Linda Schellhammer, Schlieren, Switzerland

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• P09.11 - ​​​TLR3 suppresses colorectal carcinogenesis, presumably through up-regulation of T-cell attracting CXC chemokines

Anna Sichler, München, Germany

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• P09.12 - ​​​Bifunctional SIRPα-CD123 fusion antibody for the elimination of acute myeloid leukemia stem cells

Siret Tahk, Munich, Germany

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• P09.13 - ​​​Optimization of a GMP-grade large-scale expansion protocol for Cytokine-Induced Killer cells using gas-permeable static culture flasks.

Annavera Ventura, Padua, Italy

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• P09.14 - ​​​Blocking counterregulation of unfolded protein response by targeted protein synthesis inhibition produces highly synergistic cell death in several cancer entities

Franziska Gsottberger, Erlangen, Germany

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• P09.15 - ​​​Targeting the stroma to enhance effector memory T cell infiltration and anti-tumor response to anti-PD1 antibody in pancreatic ductal adenocarcinoma

Arsen Osipov, Baltimore, United States